Hughesville is a borough in Lycoming County, Pennsylvania, United States.

Hughesville is named for Jeptha Hughes, who purchased land from John Heap in 1816 and laid out the town of "Hughesburg" before selling the entire plot to Daniel Harrold in 1820.

The town grew slowly around a gristmill that was constructed by Jacob Clayton.

[7] Early industries in Hughesville were built to serve the farmers and citizens of eastern Lycoming County.

According to the United States Census Bureau, the borough has a total area of 0.6 square miles (1.6 km2), all land.

32.4% of all households were made up of individuals, and 15.5% had someone living alone who was 65 years of age or older.