He is the founder, CEO and—jointly with his wife, biochemist Silvia Gold—the sole owner of Grupo Insud, a business conglomerate with a presence in the fields of pharmaceuticals, agroforestry, cinema, nature and design.

He continued his career, first as chief resident, and then as founder and director of the hospital's Psychiatric Emergency Unit.

[4] In the 1980s, Sigman and his family moved back to Argentina, where he developed his existing businesses and expanded to other industries.

In Argentina's veterinary industry, Grupo Insud partnered with Biogénesis Bagó, an animal vaccine production company authorized by the government of China to build a plant in that country.

[12] The company has produced the films On Probation (2005), Chronicle of an Escape (2006), Los Marziano (2010),[13] The Last Elvis (2012), Seventh Floor (2013), Wild Tales (2014),[14] The Clan (2015), The Summit (2017), and Heroic Losers (2019).

[3] Through Grupo Insud, Sigman participates in cultural companies in Argentina and Spain such as the Southern Cone edition of Le Monde diplomatique, the Latin American version of The New York Review of Books, and Capital Intelectual, which includes a line of publications in Spain under the publishing brand Clave Intelectual.

[16] By the late 1990s, Silvia Gold chaired the foundation, which has funded projects in Argentina, Spain and Ethiopia[17] addressing neglected tropical diseases (NTDs) including Chagas, dengue and soil-transmitted helminths.