Huitzilatzin (or Huitzillatzin) (died in the year Seven Reed/1499[1]) was the first tlatoani (ruler) of the pre-Columbian altepetl (ethnic state) of Huitzilopochco (now Churubusco) in the Valley of Mexico.

According to the Crónica mexicáyotl, Huitzilatzin was "quite sickly" (Nahuatl "çan cocoxcatzintli").

[3] The inhabitants of Huitzilopochco are said to have been cannibals prior to the imposition of Aztec government.

[2][4] Huitzilatzin had two children in Huitzilopochco: a son, Macuilxochitzin,[5] and a daughter, whose name is not known but who married Quauhpopocatzin, the ruler of Coyoacán.

[5] Huitzilatzin was killed in the year Seven Reed (1499), as he was held responsible for flooding that had occurred in Tenochtitlan.