[1][2] The series stars Mark Valley, Chi McBride, Jackie Earle Haley, with Indira Varma and Janet Montgomery joining the cast in the second season.

[3] The series follows the life of San Francisco-based Christopher Chance (Mark Valley), a unique private contractor, bodyguard and security expert hired to protect his clients.

Chance is accompanied by business partner Winston (Chi McBride) and hired gun Guerrero (Jackie Earle Haley).

Former client Ilsa Pucci (Indira Varma) becomes Chance's benefactor, while experienced thief Ames (Janet Montgomery) joins the team to seek redemption.

The score for the final episode of the season, "Christopher Chance", was performed by a total of 94 musicians, making it the largest live orchestra ever assembled for a television series.

In addition to the 12 episodes of the season, which have an enhanced audio mix, a number of extras are included; several unaired and deleted scenes, an audio commentary by Mark Valley, Chi McBride, Jonathan E. Steinberg and Peter Johnson for the pilot episode and two featurettes; "Human Target: Full Contact Television" and "Human Target: Confidential Informant".

[54] The set received a rating of 4.5 out of 5 from Blu-ray.com, with concerns expressed that "squeezing twelve episodes onto two discs takes a bit of a toll" and caused some artifacting.

The site also questioned the use of a lossy 640 kbit/s audio track and the small number of special features, calling it "a tad pricey for twelve episodes".

The website's critics consensus states, "Human Target is frequently preposterous, but this slam-bang action series also offers a solid mix of comedy and thrills".

[60] The New York Post stated that "because he's a human target, he has no problem blowing out of exploding buildings (of which there are too many to count) with nary a scratch.

[61] Robert Bianco wrote of the show's premiere in USA Today that the "confined-spaces fight on the train is a miniature marvel of its kind".

The website's critics consensus states: "Action-packed sequences and the addition of two central female characters give Human Target's second season a necessary boost".

[65] Brian Lowry from Variety criticized the changes made to the second season believing that the producers were forced to give the show an overhaul by the network to make it more appealing to women.

He believes the changes almost ruined the show for those who loved the first season, but he said "for all that, there are still some good moments in these early hours, and the stuntwork remains impressive".

Notably, episode 12 which aired after American Idol, received 9.3 million viewers, a season-high, and the best ratings the series has had since the beginning of the first season.