It connects the George Price Highway outside of Belmopan, Cayo District to the Southern Highway outside of Dangriga, Stann Creek District.

It partially follows, and sometimes uses the infrastructure of, the former Stann Creek Railway (see Rail transport in Belize).

All the citrus produced in Belize travels along this highway to the two major processing plants in Stann Creek district.

The traffic along the Hummingbird Highway has been on the increase lately due to an increase in demand for eco-tourism and the passage of petroleum trucks, which use the Highway as a shortcut en route to the George Price Highway (which terminates at the Guatemala border).

The highway rests in a valley which comprises citrus orchards in the lowland and untouched jungle habitat on the outskirts and beyond.