Located within the district are the port of Big Creek (the main port of Belize's banana industry), the peninsula and village of Placencia (a popular tourist destination), the villages of Santa Cruz, Alta Vista, Georgetown, Independence, Kendal, Maya Mopan, Middlesex, Mullins River, Pomona, Red Bank, Sarawee, Silk Grass, San Roman, Sittee River and the Garifuna village of Hopkins.

Within the preserve is Victoria Peak, the second highest point in Belize, at 1,120 meters (3,670 feet) above sea level.

The ethnic Garifuna village of Hopkins has recently undergone a huge transformation due to the growing tourism industry.

Placencia is home to one of Belize's most popular tourist destinations due to its large selection of resorts, guest houses, hotels and white sandy beaches.

They celebrate a diverse and rich culture that is a blend of African traditions of music, dance and religious ceremonies; Native American farming, hunting, and fishing techniques; and a French and Arawak influenced language.