The film stars Saif Ali Khan, Riteish Deshmukh, Ram Kapoor, Tamannaah Bhatia, Esha Gupta and Bipasha Basu in the lead roles, with Satish Shah, Nawab Shah, Chunky Pandey and Darshan Jariwala in supporting roles and Madhuri Dixit in cameo apperance.
During these years, Ashok's maternal uncle, Kunwar Amar Nath Singh (KANS Mama) has been in charge of his family property.
Towards this end, during a board meeting, Mamaji mixes a medicine in Ashok and Kumar's drinks, and they both start behaving like dogs.
One day Bijlani delivered a jar of cocaine to Ashok and Kumar mistaking that for flour used it for preparing parathas thereby making the customers go crazy.
On the day of the board meeting, the true Ashok and Kumar get ready to expose Mamaji, when Dr. Khan triggers the fire alarm.
Now desperate, Ashok and Kumar bump into a dance bar owner named Balbir, who (by another coincidence) is a lookalike of Mamaji.
Mamaji now does something innovative: he arranges another set of Ashok and Kumar with the help of plastic surgery from Dr. Khan's two assistants who assume their identities.
To add to the confusion, the three mental patients also storm in to help the real Ashok and Kumar, creating panic among the eyewitnesses on seeing so many lookalikes together.
"[8] The soundtrack of Humshakals is composed by Himesh Reshammiya and lyrics are written by Mayur Puri, Sameer and Shabbir Ahmed.
"[14] Sweta Kaushal of Hindustan Times rated the film 0.5 out of 5 and stated "With no story or comedy on offer, even Riteish and Ram are unable to save the day for Sajid Khan.
"[15] Mohar Basu of Koimoi gave it 0/5 stars and said the film was "[l]oaded with indecipherable dim wit" and "an odd mishmash of pathos and drudgery.
"[16] Writing in Emirates 24/7, Sneha May Francis claimed that it succeeded Khan's previous endeavor, Himmatwala, in becoming the worst Bollywood film ever.
[22] After the release of the film, leading actor Saif Ali Khan lamented that "I've been introspecting a lot and will never repeat a mistake that was Humshakals.