Khan completed his primary education from Maneckji Cooper School in Mumbai and then graduated from Mithibai College.

[5] In Kehne Mein Kya Harz Hai he played triple roles; the show made 200 episodes which were aired from 1997 to 2001.

His next directorial venture was Humshakals (2014), which is generally ranked amongst the worst Indian films of all time by critics.

He also made a brief appearance in Main Hoon Na (2004), Mujhse Shaadi Karogi (2004) and Happy New Year (2014).

[13] While filming Housefull 2 in 2011, Khan began a romantic relationship with actress Jacqueline Fernandez.

[16] In the wake of the MeToo movement in India, since October 2018, Sajid has been accused of sexual harassment by several female colleagues.

[17] Women who have accused Khan of sexual harassment include Mandana Karimi, Saloni Chopra, Rachel White, Simran Suri,[18] Marina Kuwar,[19] Aahana Kumra, Dimple Paula,[20] Sherlyn Chopra,[21] and journalist Karishma Upadhyay.