Renfrow attended Socastee High School in Myrtle Beach, South Carolina, where his father, Tim, was the football coach.

[1] Renfrow played in all 13 games as a redshirt freshman in 2015, making ten starts, and recording 492 yards and five touchdowns.

[5] In the 2017 College Football Playoff National Championship against the Alabama Crimson Tide, he caught the game-winning touchdown from quarterback Deshaun Watson with one second remaining in the game.

[14] Renfrow made his NFL debut in Week 1 against the Denver Broncos on Monday Night Football, with two catches for 13 yards in the 24–16 win.

[15] In Week 8 against the Houston Texans, Renfrow caught four passes for 88 yards including a 65-yard touchdown reception, the first of his career in the 27–24 loss.

[16] In Week 12 against the New York Jets, Renfrow caught three passes for 31 yards before exiting the game due to a rib injury in the third quarter.

After the game, Raiders' head coach Jon Gruden said that Renfrow broke a rib and punctured a lung which could force him to miss the rest of the season.

[24] In Week 14, Renfrow had 13 receptions for 117 yards and a 4-yard touchdown pass from Derek Carr in a 48–9 loss to the Kansas City Chiefs.

[27] Renfrow made his playoff debut in the Wild Card Round against the Cincinnati Bengals, catching eight passes for 58 yards in the 26–19 loss.

[29][30] In Week 2 against the Arizona Cardinals, Renfrow had seven catches for 59 yards, but fumbled twice with one recovered and returned for a touchdown by Byron Murphy in overtime in the 23-29 loss.