On July 1, 1947, the Huronia Museum first opened in a large wooden frame building that had been the family residence of James Playfair, a prominent Midland businessman.

The current museum building was Midland's Canada Centennial project and officially opened on July 1, 1967 in Little Lake Park adjacent to the Huron/Ouendat (Wendat) Village.

In 1976, the Historic Art of Huronia Gallery in the museum building opened and presently displays art by David Milne, Homer Watson, Manly MacDonald, Franklin Arbuckle, Hilton Hassell, Mary Hallen (Victorian era watercolours), William J.

The Huron Village was created by W. Wilfrid Jury (1890–1981), Director of the Museum of Indian Archaeology and Pioneer Life at the University of Western Ontario in London.

The village is modeled on Jury's work on the excavation of the pre-contact Forget site near Midland.