She began her career under the direction of Nitin Bose in New Theatre's film Daku Mansoor with actresses Umasashi and K.L.
The cast of the film included: K. L. Saigal, Uma Shashi, Prithviraj Kapoor, Husnbanu, Pahari Sanyal and Nemo.
[4] Her mother, Shareefa, was not happy with the payments of New Theatre and brought her to Bombay where Husn Banu started getting roles in Wadia films.
In 1941, Husn Banu was selected for a film named Dhandora opposite Noor Mohammad Charlie in the main role.
Husn Bano was one of the first actresses to whom famous singer Noor Jehan (who was later gone to Pakistan after independence) lent her voice in the film Dost in 1944.
Husn Banu was considered to be so beautiful and glamorous that she was featured in a Lux Soap advertisement in the early 1940s.