The Hussain Shahi dynasty was a family which ruled the late medieval Sunni Muslim Sultanate of Bengal from 1494 to 1538.

Nasrat Shah's reign is marked by a period of political instability as he had to deal with the Afghans and the growing Mughal threat.

[9] The last Sultan of the dynasty, Ghiyasuddin Mahmud Shah, who continued to rule from Sonargaon, had to contend with rising Afghan activity on his northwestern border.

Eventually, the Afghans under the Sur Empire broke through and sacked the capital in 1538 where they remained for several decades, successively establishing two independent dynasties (Muhammad Shahi and Karrani).

This loose confederacy of Bengal was ruled by Isa Khan, one of Ghiyasuddin Mahmud Shah's grandsons through his daughter Syeda Momena Khatun.