Hussey and Regan have had a long association with their respective bands having toured together, as well as each artist appearing on various recordings of the other's work.
Although they had been loosely working on ideas since 2006, in an interview with Andrew Collins on BBC 6 Music, Hussey revealed that both he and Regan were collaborating but did not have any firm plans at that time.
Hussey later announced via the Mission World Information Service (MWIS) "It's a fairly loose remit with the only criterions being that we record songs we both like and we, Julianne and I, play all the instruments ourselves...
In July 2009, Hussey announced that both he and Regan had settled on a name, being "Hussey-Regan" and said "We thought it best to christen it with a name that says what it is on the box so as to avoid any confusion".
In November 2011, the track "You'll Never Walk Alone" was released with all proceeds going to the Liverpool Football Club charity, Respect 4 All.