Huston Wyeth (1863–1925) was an American industrialist and a prominent businessman and social figure in St. Joseph, Missouri.

[4] William's brothers, John and Frank, founded the Wyeth pharmaceutical company.

Huston was a recognized breeder of cattle, trotting horses, German Shepherds and mastiffs.

This hill is on the Missouri River bluffs, overlooking the St. Joseph Branch of the Oregon Trail, and is a traditional site for couples to watch the sunset.

[10] Huston Wyeth died January 25, 1925, in Miami and is buried at Mount Mora Cemetery in Saint Joseph.