[1] Numerous species have been assigned to Hybodus spanning a large period of time, and it is currently considered a wastebasket taxon that is 'broadly polyphyletic' and requires reexamination.

[9] The males possessed claspers, specialized organs that directly insert sperm into the female, and which are still present in modern sharks.

[17] Hybodus is thought to have been an active predator which was capable of consuming swiftly moving prey,[18] probably predominantly cephalopods and, to a lesser extent, fish.

[19] Based on fossilized stomach contents, it has been proposed that Hybodus was a more active hunter than its close relatives like Asteracanthus, which likely fed on benthic prey.

[13] A preserved specimen of Hybodus hauffianus has been found with over 100 belemnite (a type of extinct squid-like cephalopod) rostra (hard mineralized internal elements) in its stomach, which may have resulted in its death.