Hydrophilicity plot

The plot has amino acid sequence of a protein on its x-axis, and degree of hydrophobicity and hydrophilicity on its y-axis.

There are a number of methods to measure the degree of interaction of polar solvents such as water with specific amino acids.

Analyzing the shape of the plot gives information about partial structure of the protein.

On the converse, amino acids with high hydrophilicity indicate that these residues are in contact with solvent, or water, and that they are therefore likely to reside on the outer surface of the protein.

The data in the above table was generated using a computer program that evaluates the average hydrophobicity of segments within a protein and uses data collected from literature.