[1] Symptoms of the condition in women may consist of menstrual irregularities, amenorrhea, abnormal vaginal bleeding, and enlargement of the uterus and breasts.

[1][2] It may also present as isosexual precocity in children[1][2] and as hypogonadism, gynecomastia, feminization, impotence, and loss of libido in males.

[citation needed] Hyperestrogenism can be caused by ovarian tumors,[2] genetic conditions such as aromatase excess syndrome (also known as familial hyperestrogenism), or overconsumption of exogenous sources of estrogen, including medications used in hormone replacement therapy and hormonal contraception.

[3] Liver cirrhosis is another cause, though through lowered metabolism of estrogen, not oversecretion or overconsumption like the aforementioned.

[citation needed] Treatment may consist of surgery in the case of tumors,[1] lower doses of estrogen in the case of exogenously-mediated estrogen excess, and estrogen-suppressing medications like gonadotropin-releasing hormone analogues and progestogens.