The term is composed of hyper - high, proinsulin - immature insulin molecule, and -emia - blood condition.

[citation needed] Hyperproinsulinemia is more frequent in type 2 diabetes.

It has been attributed to either a direct β-cells defect or an indirect effect of cell dysregulation under sustained elevated blood glucose (hyperglycemia).

[citation needed] Some alleles of insulin can cause hyperproinsulinemia (see table 2: monogenic forms of type 1 diabetes, INS (insulin).

For a more detailed descriptions of the insulin gene variations leading to hyperproinsulinemia see NCBI's OMIM 176730 This article about an endocrine, nutritional, or metabolic disease is a stub.