HVS may present with chest pain and a tingling sensation in the fingertips and around the mouth (paresthesia), in some cases resulting in the hands 'locking up' or cramping (carpopedal spasm, also known as Trousseau sign).

[10] In one study, one third of patients with HVS had "subtle but definite lung disease" that prompted them to breathe too frequently or too deeply.

"[16] While traditional intervention for an acute episode has been to have the patient breathe into a paper bag, causing rebreathing and restoration of CO₂ levels, this is not advised.

[17] The same benefits can be obtained more safely from deliberately slowing down the breathing rate by counting or looking at the second hand on a watch.

Selective serotonin reuptake inhibitors (SSRIs) can reduce the severity and frequency of hyperventilation episodes.

[18] The original traditional treatment of breathing into a paper bag to control psychologically based hyperventilation syndrome (which is now almost universally known and often shown in movies and TV dramas) was invented by New York City physician (later radiologist), Alexander Winter, M.D.