IBIS (server)

It reports, predicts and integrates multiple types of conserved interactions for protein.

A database and server IBIS (Inferred Biomolecular Interaction Server, www.ncbi.nlm.nih.gov/Structure/ibis/ibis.cgi)[1][2] developed at NCBI, National Institutes of Health, reports, predicts and integrates multiple types of conserved interactions for proteins.

IBIS also allows the mapping of a biomolecular interaction network for any given organism, human interactome derived from structural complexes is available at ftp://ftp.ncbi.nih.gov/pub/mmdb/humanIntNw/.

Binding sites which appear evolutionarily conserved among non-redundant sets of homologous proteins are given higher priority.

Together with other measures, the PSSMs are subsequently used to rank binding sites to assess how well they match the query, and to gauge the biological relevance of binding sites with respect to the query.