2BRQ, 3V4P, 3V4V369516421ENSG00000139626ENSMUSG00000001281P26010P26011NM_000889NM_013566NP_000880NP_038594Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.

The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.

[8] Beginning with the apical end of the protein, farthest from the cell membrane, the β7 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail.

The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand.

Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.