α5β1, also known as the fibronectin receptor,[1] is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.
It is the primary receptor for fibronectin.
The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).
α5β1-integrin is transported inside the cell by the kinesin KIF1C,[3] a kinesin-3 organelle transporter that walks along microtubules.
This membrane protein–related article is a stub.