The song and music video has Jack Black, Josh Homme and Dave Grohl (all in wigs) making guest appearances.

Schaffer's involvement led to Black's cameo, as the two previously worked together on a failed television pilot Awesometown, as well as a cameo by Lonely Island cohort Chester Tam, as a man who had his clothes blown off.

In 2008, the song appeared in the credits of the HBO series True Blood, and was used in the video game Gran Turismo 5 (2010).

In 2008, "I Want You So Hard" was performed live by Meat Loaf as the opening song throughout the European leg of The Casa de Carne Tour.

A recording of this was subsequently included on the bonus disc of his album Hang Cool Teddy Bear (2010).