He is currently a member of Circle Jerks, The Bronx, DOOM Regulator, Zakk Sabbath and Sugartooth, with former bands including Danzig, Wasted Youth, California Breed, Zilch, and Scott Weiland and the Wildabouts.

He recorded two albums, Lullabies to Paralyze (2005), Era Vulgaris (2007), and half of ...Like Clockwork (2013) before being fired by founding member Josh Homme during the process.

[1] Since leaving Queens of the Stone Age and Homme side project Eagles of Death Metal in 2012, Castillo joined California Breed, replacing founding member Jason Bonham, joined Scott Weiland and the Wildabouts, touring with the band before the singer's death in 2015, and joined three groups with former Queens of the Stone Age bandmate Nick Oliveri: supergroups Bloodclot (with John Joseph of Cro-Mags and Todd Youth, former Danzig and Murphy's Law guitarist), Royale Daemons (with Wino), and historic punk band Bl'ast.

From that point on, he was (with exception for Glenn) the only constant Danzig member for almost ten years, performing all percussion duties on Blackacidevil (1996), Satan's Child (1999) and I Luciferi (2002).

Castillo joined Queens of the Stone Age without an audition, playing through half a song (Avon) at a last-minute rehearsal when frontman Josh Homme reportedly walked out of the room, and returned saying "I just fired the drummer.

Castillo also played on side projects including Mark Lanegan's solo album Bubblegum, Desert Sessions Vol.

[11] After leaving QotSA in 2012, Castillo has had great demand as a session player, touring musician as well as becoming a proper band member in numerous projects.

Notably, on June 25, 2017, Castillo, along with Trent Reznor, Mariqueen Maandig Reznor, Robin Finck, Atticus Ross, and Alessandro Cortini appeared as "The Nine Inch Nails" in Episode 8 of Twin Peaks: The Return, performing an alternate live rendition of the song "She's Gone Away", which had appeared on Nine Inch Nails' 2016 album Not the Actual Events.

In July 2021, hardcore punk band Circle Jerks announced that Castillo would be their new drummer and he would join them on their reunion tour to celebrate the 40th anniversary of their 1980 album Group Sex.

Castillo used DW drums and hardware, Paiste cymbals and Remo heads during the Songs for the Deaf tour, occasionally using PDP kits for one-off performances.