The story revolves around an unnamed male protagonist, a high school student who prefers to spend his time reading, and his relationship with his classmate, Yamauchi Sakura, a cheerful and popular girl who is secretly suffering from a terminal illness affecting her pancreas.

The story takes a tragic turn when Yamauchi Sakura is murdered in an alleyway, becoming a victim of a random killer, leaving the protagonist to deal with his grief and the unanswered questions about their relationship.

He never attends Sakura's funeral, but eventually musters the courage to visit her parents at her house, where he receives her book, "Living with Dying," as per her wishes.

The protagonist, Haruki, ultimately learns that Sakura had come to love him, despite her stated reluctance to form a romantic bond, and that she had also come to recognize his need for connection.

Yoru Sumino originally published the novel as a web novel on the user-generated content site Shōsetsuka ni Narō in 2014, before Futabasha republished it with cover art by loundraw on June 19, 2015 (ISBN 978-4-575-23905-8).

[5] Izumi Kirihara began serializing a manga adaptation in Futabasha's Monthly Action magazine on August 25, 2016,[6][1] and ended the series on May 25, 2017.

[5] A Japanese live-action film based on the novel, titled Let Me Eat Your Pancreas,[10] starring Takumi Kitamura and Minami Hamabe in the lead roles premiered in Japan on July 28, 2017.

[1] The film is written for the screen and directed by Shinichiro Ushijima and produced by Keiji Mita at Studio VOLN,[13] with music composed by Hiroko Sebu.