Founded in 1887, it had 325 combined locations, including 190 bank branches and three loan production offices in 12 states primarily throughout the South.

Its principal industry was sugarcane farming, as the area's oil reserves, which would later spur population and economic growth, had yet to be discovered.

Since savings and loan associations, or "thrifts," could not lend to businesses, ISLA was not affected by the oil crisis in the early 1980s like many Louisiana commercial banks were.

[8] When Hurricane Katrina hit the gulf coast in 2005, IberiaBank incurred hurricane-related expenses including loan losses associated with the storm, facility repairs and insurance deductible payments.

Being a bank solely based in Louisiana, the organization decided to diversify its geographic footprint in the years following the storm to minimize risk.

[10] Spring of 2008 began a period of rapid growth fueled by accumulating the assets of failed banks in the aftermath of the 2007–2008 financial crisis.

(Miami, Florida)[citation needed] In November 2019, IBERIABANK and Memphis, Tennessee-based First Horizon Corporation agreed to a merger.

[2] Iberia Capital Partners (ICP) was a subsidiary of IBERIABANK that performed equity research, institutional sales, trading, and investment banking.

IWA provided wealth management and trust services for high net worth individuals, their families, corporations, pension funds, foundations, endowments, and public and private institutions.

[39] Mercantile Capital Corporation was a subsidiary of IBERIABANK which lent to small business seeking to acquire real estate and equipment using the SBA 504 Loan Program.