In its course, after joining San Matéo, it is called Ichilo, flowing in a northerly direction, where it forms the border between the Cochabamba Department and the Santa Cruz Department.

From its source to the mouth into the Amazon, the river has a total length of 2,455 km.

The Ichilo is one of the Bolivian rivers with a high amount of water.

The most important tributaries of the Ichilo are the Bolivian Río Grande, Chapare, Piraí, Sacta, Víbora, Chimoré, Choré, Ibaresito, Ibabo and Useuta rivers.

Ichilo River passes the metropolitan area of Santa Cruz in the west, the largest cities on the riverbanks is Puerto Villaroel.