SH-43 begins at an intersection with U.S. Route 26 controlled by a traffic light in the community of Beachs Corner.

After returning to a rural environment, SH-43 crosses a canal and continues north past 97th Road.

It enters the city of Ucon, passing an auto parts yard to the west.

The highway turns west onto 4th Street and continues northeast across a railroad.

It leaves the Ucon city limits before terminating at U.S. Route 20.