She represented the culture of Lithuania Minor and Klaipėda Region, territories of German East Prussia with historically large, but dwindling, Lithuanian populations.
Simonaitytė was born in a small village of Vanagai (then Wannaggen in German East Prussia) in Klaipėda District Municipality.
She returned in better health and, influenced by World War I, began her literary career publishing poems and short stories in various Lithuanian periodicals of the Lithuania Minor.
[1] After the 1939 German ultimatum to Lithuania, Klaipėda was attached to Nazi Germany and Simonaitytė moved to Kaunas and in 1963 to Vilnius.
Simonaitytė's most famous novel, Aukštujų Šimonių likimas, depicted the fate of the Šimoniai family between the 18th and 20th centuries through independent fragments.
Simonaitytė's biggest weaknesses included excessive wordiness, tendency towards sentimentality, and, in later works, use of clichés of socialist realism.