He played college football for the Oregon Ducks and was selected by the Cleveland Browns in the seventh round of the 2015 NFL draft.

He was praised by Duck's longtime secondary coach John Neal as, "(...) the best player I've ever coached.”[5] Despite being projected as a late first-round draft selection in the 2014 NFL draft, Ekpre-Olomu decided to return for his senior season at the University of Oregon to complete his degree in general social science.

[5] He was named first-team All-Pac-12 Conference and third-team All-American by the Associated Press[7] as a sophomore in 2012 after starting 13 games and recording 59 tackles with four interceptions.

Later in the year, Ekpre-Olomu sustained a knee injury which ended his season prior to the 2015 Rose Bowl, in which Oregon received the second seed for the new College Football Playoff.

However, an anterior cruciate ligament injury (ACL) he suffered in December 2014 during practice left many teams no longer interested in him.

[23][24] His parents Joshua and Queen Ekpre-Olomu are Nigerian, and his birth name of Ifomeno means "something that fits you well.