[3] He made his first-team debut on 1 March 2008, starting, playing 68 minutes and being booked as the Colchoneros won 4–2 at home over FC Barcelona; he had just signed his first professional contract two months earlier.

The following campaign, he appeared even more rarely – no minutes in the league whatsoever – and, in late December 2010, was transferred to Málaga CF, with teammate Sergio Asenjo also making the move in a loan deal.

In January 2013, he was a central figure in two of the three fixtures between Málaga and Barcelona: on the 13th, his backpass turned into an assist for Lionel Messi for the first in an eventual 1–3 home loss;[11] three days later, he scored in the last minute to earn his team, by then reduced to ten men, a 2–2 draw at the Camp Nou in the quarter-finals of the domestic cup (6–4 aggregate defeat).

[17] A long-term ankle injury ruled him out for a large part of the campaign, but he returned in March 2018 as the permanent captain of the side following Gómez's departure to VfB Stuttgart two months prior.

On 7 November 2014, Camacho was called up to full side manager Vicente del Bosque's squad for matches against Belarus and Germany,[21] He made his debut on the 18th against the latter, coming on as a half-time substitute for Sergio Busquets in an eventual 0–1 friendly loss in Vigo.