Ignazio Guidi (1844 – 18 April 1935) was an Italian orientalist.
He became professor at the University of Rome.
He learned semitic languages from Pius Zingerle and Father Vincenti, and taught himself Ge'ez.
He also edited for the first time a letter of Simeon of Beth Arsham about the martyrs of Najran, the oldest evidence for this historical event.
He was the student of the Ethiopian scholar Däbtära Keflä-Giorgis, who played a "crucial role as teacher of the person who could be described as the father of Ethiopian studies in Italy, Ignazio Guidi.