She was the running mate of Rumen Radev, who defeated GERB nominee Tsetska Tsacheva in the second round of the 2016 presidential election.

She received a master's degree in Bulgarian and French philology from the University of Sofia and later specialized at the École nationale d'administration (ENA, National School of Administration) in Strasbourg, France, and the Center for European Studies (CEES) of the University of Strasbourg.

[citation needed] From 1990 to 1997, Iotova worked at Bulgarian National Television as a reporter, editor, director and presenter of news and current affairs programmes.

From the 2014 elections, she served as vice-chairwoman of the Committee on Civil Liberties, Justice and Home Affairs, under the leadership of chairman Claude Moraes.

In this capacity, she was her parliamentary group's rapporteur on a 2015 report calling for the equitable distribution of 40,000 refugees across the European Union.