[3] Starting at I-72/US 36 interchange at East Hannibal, IL 106 travels southeastward before turning eastward near Aladdin.

After crossing the bridge, the concurrency continues until IL 100 branches north near Bloomfield.

It passes Alsey and Barrow before terminating at US 67 near downtown White Hall.

[3] SBI Route 106 was the current Illinois 106 from East Hannibal to Kinderhook.

Inspections suggested that continued use of the lift span could harm the structural integrity of the bridge.