It travels from Short Street (near Lake Drive and 1⁄4 mile (0.40 km) northwest of Interstate 255) in Centreville to IL 104 in Waverly.

[3] A second new alignment, Bellwood Road Extension in Bethalto, opened a few years later that would link IL 111 up with Vaughn and Central in Wood River.

The original alignment of IL 111 in Alton had it cut up Sixth Street in Wood River, Old Alton–Edwardsville Road (with a concurrency with then-IL 159), and up Broadway in Alton until its concurrency with US 67 using Belle Street.

SBI Route 111 originally traveled from Waverly to Alton on modern-day IL 111.

In 2001, when US 67 was moved west through Jerseyville, IL 267 took its place north of Medora.