Illinois Route 151 is a north–south state road in southern Illinois located entirely within Jackson County.

[1] Illinois 151 serves as a connector through the northwest portion of Shawnee National Forest.

It also is the access road to the Jackson Creek Recreational Area.

SBI Route 151 originally ran from Steeleville to Murphysboro; this was absorbed into Illinois Route 43 in 1937, and eventually became part of Illinois 4 in 1964.

[2] The entire route is in Jackson County.