The highway, which is locally known as Main Street for its entire length, heads east from this intersection toward Du Quoin.

After passing CR 25, the road heads northeast for a short distance before turning east into Du Quoin.

CR 7 picks up the Main Street name and continues east into downtown Du Quoin, and US 51 travels north and south from the junction.

IL 152 is one of the shorter routes on the Illinois State Highway System.

The road which is currently Route 152 first appeared on Illinois highway maps in 1924, though it was not marked at the time.