The school was opened in 1941 and was operated by the Sisters, Servants of the Immaculate Heart of Mary.

In the early 20th century, the Sisters of IHM had a strong presence in Detroit, staffing a large number of elementary schools as well as Marygrove College.

Bohlen & Son to design the new high school, and ground was broken in February 1941 and dedicated in October of the same year.

The school offered a wide variety of courses, focusing on a college preparatory curriculum.

[5] In the mid-1980s, the sisters rented the building to CareerWorks, Inc., a company that taught basic job search skills.

[5] Immaculata High School is a three-story, flat-roofed L-shaped building constructed in a vernacular Modernstyle with Art Deco influences.