Two years later on 26 July 1870, the Royal Württemberg State Railways (Königlich Württembergischen Staats-Eisenbahnen) inaugurated the 9.7 km-long route between Tuttlingen and Immendingen, the last piece of the Upper Neckar Railway, providing a continuous connection from Immendingen via Tübingen to Stuttgart.

It also opened the ten-kilometre section from Tuttlingen junction on 26 November 1890, completing the Danube Valley Railway to Ulm via Sigmaringen.

The section of the line from Immendingen junction to the junction with the Wutach Valley Railway at the neighbouring Hintschingen station was put into operation for military reasons on 20 May 1890, a few months before the completion of the Danube Valley Railway, with trains generally running from or to Immendingen.

Initially the incorporation of the two state railways into the newly formed Deutsche Reichsbahn in 1920 did not change the function of the station.

The largest hall with seven entrances was built at the west end of the station together with an accommodation building for drivers from Zimmern and the associated tracks.

Immendingen station is served by a pair of InterCity trains, the Bodensee, running between Emden and Konstanz and operated by Deutsche Bahn long-distance services.

This station is frequently used in the summer months to reach the tourist regions of the Black Forest and Lake Constance by rail.

A pair of IC trains called the Schwarzwald from Hamburg to Konstanz was abandoned in December 2014 due to low usage.