Impute.me was an open-source non-profit web application that allowed members of the public to use their data from direct-to-consumer (DTC) genetic tests (including tests from 23andMe and Ancestry.com) to calculate polygenic risk scores (PRS) for complex diseases and cognitive and personality traits.
[6][7] Impute.me calculates PRSs, which are used to estimate the risk of developing complex diseases from the combined effects of numerous common single nucleotide polymorphisms in the human genome.
[1] The data is then subjected to analysis scripts including PRS calculations for approximately 2,000 traits and complex diseases.
[1] Users can then make use of the web tool GenoPred[12] to translate their PRSs onto an absolute risk scale using summary statistics from the GWAS studies.
[16] Notably, this criticism match the FDA-regulation imposed on the major direct-to-consumer genetics company 23andme.