The series stars Gabrielle Creevy, James Wilbraham, Poppy Lee Friar, Jo Hartley, Aled ap Steffan, Di Botcher, Georgia Furlong and Rhodri Meilir.

Creator and writer Kayleigh Llewellyn stated that her draft for the series was "warmly received" by the BBC, and director Lucy Forbes joined the project due to "the power of the subject matter".

Llewellyn explained that she and casting director Rachel Sheridan were focused on having local Welsh actors appear in the series, as they could bring the "characters to life".

[14] Annie Lord, writing for The Independent, described In My Skin as a "hilariously dark coming-of-age drama [that] cuts deep", and that "Llewellyn's dialogue is caustic and sharp".

[16] Time wrote: "A combination of black humor, raw depictions of trauma and authentic performances mark the series as part of the same wave of British TV that includes auteurs like Phoebe Waller-Bridge and Michaela Coel.

[8] In November 2021, the second series of this Welsh comedy drama would receive 5 stars in Rebecca Nicholson's Guardian TV review, stating that it is "a poignant must-see which deserves widespread acclaim".