Set 10 years after the first anime Inazuma Eleven, a new soccer system is implemented where the results of matches are predetermined even down to the point scoring.

With the assistance of Fei Rune and Clark Wonderbot, both came from the future, Tenma and his friends must defeat El Dorado in order to return soccer to the world.

Later, as Shinsei Inazuma Japan advanced through the Asia premilinaries, a terrible truth unfolds—FFIV2 is actually the preliminaries of District A of an interplanetary tournament: Grand Celesta Galaxy.

The first animated film, Inazuma Eleven GO: Kyūkyoku no Kizuna Gurifon (イナズマイレブンGO 究極の絆 グリフォン), premiered in Japanese theaters on December 23, 2011.

In 2012, the crossover Inazuma Eleven GO vs. Danbōru Senki W film was revealed on the July issue of Shogakukan's Monthly Corocoro Comic magazine.