Indeloxazine (INN) (Elen, Noin) is an antidepressant and cerebral activator[1][2] that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition.

[5] Indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist.

[6][7] It has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor via its action as a serotonin releasing agent.

[8][9][10] The drug has been found to possess nootropic,[11][12] neuroprotective,[13][14][15][16] anticonvulsant,[17] and antidepressant-like effects in animal models.

[1][6] This drug article relating to the nervous system is a stub.