5-Methoxy-α-ethyltryptamine (5-MeO-α-ET) is a psychoactive drug and member of the tryptamine chemical class.

It reportedly produces psychedelic and stimulant effects.

[1] 5-MeO-α-ET, when used recreationally, is usually taken orally at dosages of 50–75 mg. 5-MeO-α-ET produces entactogenic and stimulant effects that can last 4–6 hours.

There have been no reported deaths or hospitalizations from 5-MeO-α-ET, but its safety profile is unknown.

5-MeO-α-ET is unscheduled and uncontrolled in the United States, but possession and sales of 5-MeO-α-ET could be prosecuted under the Federal Analog Act because of its structural similarities to α-ET and α-MT.