[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.
[2] Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae).
These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs.
[3] Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.
[6] Treatment include 5% 5-fluorouracil cream, topical pure coal tar, electron beam therapy, phototherapy, and total excision.