Progressive nodular histiocytosis is a cutaneous condition clinically characterized by the development of two types of skin lesions: superficial papules and deeper larger subcutaneous nodules.
[4] Progressive nodular histiocytosis's clinical course is characterized by an unwavering lack of spontaneous remission.
[8] Mechanical interference caused by lesions in critical locations, such as the eyelids or the soles of the feet, can result in functional impairment.
[8][9] There is a rare possibility that the cutaneous lesions could cause systemic effects directly; microcytic anemia due to significant intralesional iron sequestration has been documented.
[10] Other treatments such as carbon dioxide laser, intralesional as well as systemic steroids,[8] and antineoplastic agents such as imatinib have mostly shown no effect on progressive nodular histiocytosis.