The highway runs parallel to a rail line in a northwest-to-southeast direction in rural LaPorte and St. Joseph counties.

SR 104 continues southeast now paralleling the Norfolk Southern track and enters St. Joseph County.

[2][3][4] No segment of State Road 104 in Indiana is included in the National Highway System (NHS).

[5] The NHS is a network of highways that are identified as being most important for the economy, mobility and defense of the nation.

In 2016, INDOT figured that lowest traffic levels were 1,163 vehicles used the highway daily from at the La Port–St.