SR 152 serves as a connector route through Hammond between US 41 and US 20, traveling entirely along Indianapolis Boulevard.

The route begins at a combination interchange with I-80/I-94/US 6/US 41 (Borman Expressway).

After US 41 turns west onto the expressway from Indianapolis Boulevard, the roadway continues north in a straight direction, now carrying SR 152.

North of the interchange, SR 152 serves the Purdue University Northwest (Hammond campus).

North of 165th Street, the route begins to transition into an industrial area.