State Road 58 runs from Merom in the west to Columbus in the east, a distance of approximately 122 miles (196 km).

SR 58 heads south and east towards Carlisle.

In Freelandville SR 58 has an intersection with the northern terminus of State Road 159.

SR 58 passes through the north part of Bedford and then heads northeast towards Columbus.

[3] Original SR 58 followed the same route State Road 156 follows in southeastern Indiana.