Administered by the United States Department of Veterans Affairs, it occupies approximately 677 acres (2.74 km2), and has over 60,000 interments, as of 2021.

Indiantown Gap derives its name from the various Native American communities that populated the region.

Starting in the 1930s, it became a training area for the United States Army and control of the facility was turned over to the Pennsylvania National Guard in 1998.

In 1976, a section of Fort Indiantown Gap Military Reservation was selected as the national cemetery for the states of Delaware, Maryland, New Jersey, Virginia and West Virginia.

The Commonwealth of Pennsylvania donated land for the site to the US Veterans Administration (now known as the United States Department of Veterans Affairs), specifically the branch of the VA known as the National Cemetery Administration (NCA).